Metabolic Consequences of Muscle Disuse Atrophy
نویسندگان
چکیده
منابع مشابه
Muscle Deconditioning and Disuse Atrophy
Lack of physical activity can cause a muscle to atrophy. Muscle deconditioning may become apparent within days to weeks of decreased physical activity. For example, we have all known individuals who were physically fit during their high school days and then became less active over time. The cessation of regular activity causes the muscles to decrease in size, but contrary to what some people sa...
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Long periods of skeletal muscle inactivity (e.g. prolonged bed rest or limb immobilization) results in a loss of muscle protein and fibre atrophy. This disuse-induced muscle atrophy is due to both a decrease in protein synthesis and increased protein breakdown. Although numerous factors contribute to the regulation of the rates of protein breakdown and synthesis in skeletal muscle, it has been ...
متن کاملOxidative stress and disuse muscle atrophy.
Skeletal muscle inactivity is associated with a loss of muscle protein and reduced force-generating capacity. This disuse-induced muscle atrophy results from both increased proteolysis and decreased protein synthesis. Investigations of the cell signaling pathways that regulate disuse muscle atrophy have increased our understanding of this complex process. Emerging evidence implicates oxidative ...
متن کاملMitochondrial signaling contributes to disuse muscle atrophy.
It is well established that long durations of bed rest, limb immobilization, or reduced activity in respiratory muscles during mechanical ventilation results in skeletal muscle atrophy in humans and other animals. The idea that mitochondrial damage/dysfunction contributes to disuse muscle atrophy originated over 40 years ago. These early studies were largely descriptive and did not provide uneq...
متن کاملMechanisms of disuse muscle atrophy: role of oxidative stress.
Prolonged periods of skeletal muscle inactivity lead to a loss of muscle protein and strength. Advances in cell biology have progressed our understanding of those factors that contribute to muscle atrophy. To this end, abundant evidence implicates oxidative stress as a potential regulator of proteolytic pathways leading to muscle atrophy during periods of prolonged disuse. This review will addr...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2005
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/135.7.1824s